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As shown in Figure 1 (1-2), the SWCNTs caused an overall change in alveolar architecture with the exception of focal collections of alveolar macrophages laden with particles; lung tissue thickening as a prelude to the development of fibrosis was evident and progressive (Figure 1 (1-2D,G)), and such effects were absent in the lungs of the control group.
These ideas support the model of an activation of the innate inflammatory response in microglia as a prelude to the development of AD [ 39].
Further follow-up study on patient progress is required to determine whether such colonization is a prelude to the development of co-morbidity due to invasive or disseminated fungal disease and if so, to work out the time kinetics and nature of such progression.
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Accordingly, the development of prophylactic or therapeutic passive-immunization strategies using antipeptide antibodies is a plausible prelude to the development of corresponding active-immunization strategies using peptide-based vaccines.
This conceptual program is seen as the prelude to the development of empirical theories of delusion, in which philosophers work alongside cognitive scientists (Davies and Coltheart 2000).
The ministry "rejects that promising findings in basic research or preliminary results in animal models be conveyed to society as if they already were the prelude to the development of valid drugs".
The frescoes by Johann Michael Rottmayr in the castle of Vranov in Moravia (1695) and in Breslau (now Wrocław; 1704 06) constitute a prelude to the great development of Baroque painting in the Habsburg domains.
As El-Hibri comments, "in time this development represented a prelude to the emergence of autonomous provincial dynasties in the east, which would relate to the caliphal centre in nominal terms of loyalty only".
The arteriolar tortuosity with pseudoaneurysms together with the presence of foamy vacuolated cells in the tunica media may illustrate the development of vascular fragility and may be a prelude to the later formation of aneurysms.
Third, the development of a massively parallel sensor assay for unbiased, high-throughput, functional evaluation of shRNA sequences is a prelude to the production of next-generation genome-wide shRNA resources that will be more potent and less noisy than the existing libraries.
Yale had arrived on the national stage, a prelude to the achievements of the current season.
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