Overall dose levels were selected based on results of a preliminary dose-range finding studose-range findingnd lactating ratstudy
When a preliminary ("priming") dose of Cy at 50 mg/kg was given 7, 9 or 14 days before a single large dose of 250 mg/kg, lung damage was reduced, as shown by a smaller increase in ventilation rate than in those receiving 250 mg/kg alone, and this difference was significant (P less than 0.01) in the Day-14-and highly significant (P<0.001) in the Day-7- primed" Day-7- primed
A preliminary test dose of pramlintide, 15 μg by subcutaneous injection, equivalent to half the protocol dose, was given in the right or left deltoid before dinner to assess the effect of pramlintide on meal tolerance in these drug-naive subjects.
We performed preliminary dose- and size-dependent measurements of the effects of NPs on plant biomass under these particular growth conditions.
Based on these preliminary data, a dose of 10 mg/kg was chosen for evaluation of dasatinib efficacy.
A preliminary clinical dose-finding and safety study of these three antivenoms was carried out in 24 patients with incoagulable blood after E. ocellatus bites who were not severely envenomed.
The rats were expected to tolerate the doses; because a preliminary study of 15 days found no acute toxicity and the lethal dose 50 (LD50) was greater than 5000 mg/kg [ 21].
As a part of the project concerning the irradiation of a section of the human liver left lobe, a preliminary estimation of the expected dose was performed.
This concentration was considered to be suitable for a combination treatment with AZT on the basis of preliminary dose-dependent experiments which showed that Bay 11 7085 at 1 μM did not induce significant apoptosis by itself on U937 cells (data not shown).
After the establishment of MTD, dose expansion was undertaken to better estimate the tolerability of this dose and provide a preliminary assessment of efficacy.
The World Health Organization releases a preliminary estimate of the radiation doses received by the public during the meltdowns at the Fukushima Daiichi nuclear plant in Japan.
