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This element seems to have a preferred insertion site at the tnpA gene of a blaTEM-carrying Tn3-like transposon, the latter also being inserted by a transposition event.
This element seems to have a preferred insertion site at the tnpA gene of a blaTEM-carrying Tn3-like transposon, the latter itself being inserted by a transposition event.
In addition, DINE-I has a preferred insertion site of "TT" and partial RepHel coding sequences were found to be associated with some elements.
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TEs can insert into virtually any portion of the host genome; however, certain preferred insertion regions have already been reported, such as in ribosomal genes [ 39, 40].
The high proportion of GC-poor LHGRs is seemingly due to the preferred insertion of interspersed repeated sequences in these families, as well as the sequence expansion phenomena [26].
In the future, we may need to introduce more variation in the CDR3 loop length in combination with the preferred insertion of Cys into defined CDR3 positions.
While TSDs and "dissimilar" TSDs flanking the CitMule elements are certainly TA rich sequences, Figure 5 suggests that the preferred insertion sites of CitMule are bendable A/T triplets.
Hence it is reasonable to believe that the sequences preferentially nicked by the EN could be the preferred insertion sites of the retrotransposon, and the behavior of EN might influence the choice of target site of a non LTR retrotransposon.
In addition, to detect whether the preferred insertion site of IS 6110, DK1 region [ 28], in low-copy number strains (LCS) (< 7 copies) is present or absent in high-copy number strains (HCS), a specific pair of primers was designed.
It is yet unclear if the highly repetitive nature of the tRNA genes themselves or the preferred insertion of TE elements in proximity to these tRNA genes is the mediator of ectopic recombination [ 54, 55].
As far as the larger size of the GC-poorest isochore families of vertebrates is concerned, this may be due to the preferred insertion in these families of interspersed repeated sequences, as well as to sequence expansion phenomena [ 1].
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