However, a preferential retention of effector memory over central memory lymphocytes has been observed in most donors.
Exogenous treatment with inflammatory stimuli could not reverse preferential memory conversion of the late recruited cells, suggesting that the antigenic load is likely the main factor that contributes to memory formation, possibly determined by the number of T cell to APC contacts.
Oligoclonal CD8+ T cells from the blood of relapsing-remitting patients displayed a preferential central-memory (CM) phenotype with increased homing and cytotoxic abilities.
This suggests that memory B cells with less migratory capacity remain in the blood as a result of the selective migration and retention of CXCR4+CXCR5+ memory B cells into the inflamed glands and thereby supports recent immunophenotypic and molecular studies in pSS, indicating a preferential accumulation of memory B cells in the salivary gland infiltrates [ 24, 79].
We paid special attention to the bone marrow because it is a preferential homing site for memory T cells, and memory CD8 T cells proliferate more extensively in the bone marrow than they do in either secondary lymphoid or extra-lymphoid organs [27].
Here, we first review several observations showing that the bone marrow can function as a secondary lymphoid organ for both CD4 and CD8 cells, as well as a preferential homing site for memory T cells.
Consistent with the fact that the bone marrow is a preferential homing site for memory T cells [27], [30], the frequency of H7a-specific T cells was higher in the bone marrow than the spleen of B10.H7b mice (P<0.01).
We also did not detect vaccine-reactive T cells in the bone marrow, a preferential homing side of memory T cells [ 38].
Several lines of evidence suggest that the septal HPC [dorsal HPC (dHPC) in rodents, posterior HPC in primates] plays a preferential role in spatial memory, whereas the temporal HPC [ventral HPC (vHPC) in rodents, anterior HPC in primates] plays a preferential role in anxiety (Bannerman et al., 2004).
Based on prior theoretical and empirical work (Wang et al., 2010), we hypothesized that the DN would have a preferential positive relationship with memory; however, based on the results of Andrews-Hanna and colleagues (2007), we examined the alternative hypothesis of a positive correlation between the DN and all cognitive domains.
