Status epilepticus models of epileptogenesis possess the advantage of a clear-cut progression from initial insult to chronic epilepsy in contrast to electrical kindling where a predominantly time-dependent protocol is usually administered.
Of note, however, even with an increased dose, the attainment of PD targets may still be unreliable, because beta-lactams have predominantly time-dependent kill characteristics, i.e., the time that the unbound (or free) concentration is above the MIC (f T>MIC) is the major PK/PD index associated with bacterial killing [51 53].
The activity of β-lactams is predominantly time-dependent and requires serum and tissue antibiotic concentrations above the minimal inhibitory concentration (MIC) of the pathogen to achieve adequate bacterial killing [ 6].
Of note, however, even with an increased dose, the attainment of PD targets may still be unreliable, because beta-lactams have predominantly time-dependent kill characteristics, i.e., the time that the unbound (or free) concentration is above the MIC (fT>MIC) is the major PK/PD index associated with bacterial killing [ 51- 53].
It is, for the first time, a predominantly urban nation, with just over half its 1.4 billion citizens living in cities.
He had an instinct for sales, and one of his first projects was renting out a new high-rise office building at 445 Park Avenue, at that time a predominantly residential area.
Not all of the cases were as clear cut as Howard Beach or Bensonhurst, another case where a black teen, Yusuf Hawkins, was killed when he too wandered into a predominantly white enclave, this time in Brooklyn.
She produced an ambitious revival of James's work, this time with a predominantly black cast.
Given that we saw a similar bounce in a predominantly risk-off environment this time last week, investors now need only ask one question: do they feel lucky?
Making its fifth bid, Istanbul would offer a transcontinental Games that straddle Europe and Asia and place the Olympics for the first time in a predominantly Muslim country.
I expected this book to be quite sad and give a predominantly negative outlook of the time the twins spend in school, but it is awe-inspiring and uplifting in a way that only a beautifully written book can achieve.
