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The phrase "a predominant side effect" is correct and usable in written English.
It can be used when discussing the most common or significant side effect of a medication or treatment.
Example: "The study revealed that a predominant side effect of the new drug was severe headaches."
Alternatives: "a major side effect" or "a primary side effect".
Exact(1)
As skin toxicity is a predominant side effect of many specific EGFR-TKI (Li and Perez-Soler, 2009), the question here is whether any of the other target inhibiting effects acts as main driver of the therapeutic potential of JNJ-26483327.
Similar(59)
Asthenia was the predominant side effect.
Somnolence, sedation, constipation, thrombosis and neuropathy are predominant side effects of thalidomide, whereas neuropathy and the inconvenience of parenteral administration makes bortezomib unattractive, especially in elderly population.
A side effect of a medication(s).
Cabazitaxel did have a serious side effect.
It is a dangerous side effect.
A common side effect is headache.
"That's a good side effect".
"It's a nice side effect".
"It's a fortunate side effect.
I develop a serious side effect.
More suggestions(2)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com