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But a predisposition is not destiny.
Clearly a predisposition is required, and this is highly likely to be genetic.
Such a predisposition is likely to be especially important in influencing whether infection becomes established after inhalation of B. pseudomallei.
So from that point of view I think, clearly, that genetics in starting with a predisposition is a better concept than that it is a progression from SIRS to severe sepsis.
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There is no apparent reason why a predisposition was seen for males.
According to the modified Duke's criteria [ 14] one major criterion (vegetation on the aortic valve) and two minor criteria (fever and aortic valve stenosis as a predisposition) were present, leading to the diagnosis of a possible infective endocarditis (IE).
In particular it suggested that the presence of a genetic predisposition is not always a sufficient condition for developing the disease.
In addition, a genetic predisposition is suggested with a mutation in the p53 tumor suppressor and k-ras genes seen in intrahepatic and extrahepatic CCA respectively [ 19].
There is a high breed predisposition to chronic valvular disease and therefore a genetic predisposition is highly suspect [ 1- 3] with a clear majority of affected breeds being of small size [ 10].
And a genetic predisposition is just that: it is not destiny, but rather a tendency that can be encouraged or discouraged to express itself by how we live our lives.
However, 28.4% were interested in more information on how DNA works, 35.8% in what a genetic predisposition is and 50.9% in the working mechanism of a genetic test.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com