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This approach will require a multi-element low impedance electrode with a sufficient stimulation range to evoke variable intensities of perception and a predictable spread of contacts to engage separate digits.
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City blocks once strewn with family-owned businesses are a depressingly predictable spread: CVS.
However, the spatial topography of AD and PD pathology supports the notion that inclusions form and progressively spread in a predictable neuroanatomic sequence.
An important pathological hallmark of PD is the presence of α-synuclein inclusion bodies, i.e. Lewy bodies (LBs) and Lewy neurites (LNs), which spread in a predictable manner throughout the brain [ 9].
Gastric cancer spreads in a predictable fashion through the gastric wall with the presence of perigastric fat stranding and nodular outline suggestive of serosal involvement (T3 tumours) (Fig. 1).
Lymphatic spread usually occurs in a predictable way, from superior to inferior, the upper parajugular lymph nodes (level II) being the first echelon at risk.
Analytic adoption spreads through organizations in a predictable pattern, as all respondents gained proficiency with functional analytics in the same order.
Lymphatic spread (Table 3) occurs in a predictable way usually to periparotid lymph nodes and level 2 and 3 lymph nodes.
These challenges can be addressed with therapies that boost the quality and magnitude of an immune response in a predictable, designable fashion that can be applied for wide-spread use.
Earlier post-mortem studies of Lewy pathology in PD brains had led to the proposal that it gradually spreads throughout the nervous system following a predictable anatomical pattern [ 6, 8].
But it is also a vulnerable organ, prey to the excesses of a modern western lifestyle – and as excessive lifestyles have spread around the globe, they have had a predictable effect.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com