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We used the PEBCRES simulation framework (He et al. 2012; Duque et al. 2014) (fig. 1 A and B) to evolve sequences that drive a predetermined expression pattern, simulating the process of evolutionary adaptation under a variety of scenarios.
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To better illustrate and map co-regulated genes with different activation and deactivation profiles, the levels of every transcript have been assigned to graphs of "Expression Waves" that follow a particular, predetermined, expression pattern (Figure 5).
Here, CRMs were evolved in silico to drive predetermined expression patterns along the A/ P axis.
The generation of further Ad5 complementing cell lines from any of the LoxP parent cell lines isolated here should be facilitated as the cell lines obtained will have predetermined expression properties.
The PITT technique enables targeted integration of a single-copy transgene into a predetermined locus by Cre-loxP-mediated recombination and guarantees a stable and reproducible transgene expression.
This is not a predetermined process".
Its policies will be an "ideologically driven improvisation" rather than a predetermined blueprint.
A plethora of electronic, hydraulic and mechanical devices adjust engine parameters according to a predetermined scheme.
At a predesignated time, this Trojan horse program begins to send messages to a predetermined site.
Investigators concluded that the explosion was conducted at a predetermined time.
Did the review have a predetermined protocol?
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