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For example, for each exon skipping event, we require that the 'skip' probeset and at least one of the three 'include' probesets (see Fig. 1A) have P-values below a predefined significance cutoff (default is 0.001), and that significant 'include' and 'skip' probesets display opposite directions of change in splicing index between the two sample groups.
Heterogeneity was quantified with a Chi-square heterogeneity statistic and by means of I square, with a predefined significance threshold of 0.1 [ 36].
Furthermore, we used a stepwise backward selection procedure, using a predefined significance level of > 20% for removing predictors from the models [ 8].
If a gene has an associated p-value less than a predefined significance level after correcting for multiple testing, this gene is deemed to be differentially expressed.
For a P value smaller or equal to a predefined significance level (here set to 0.05), the window is considered to contain UEs, that is, significant excess spike synchrony.
Leaving out one sample (technical replicate) at a time, we applied the greedy.wilks method to select genes showing p-values from F-statistic of the partial Wilk's Lambda (p.value.diff) smaller than a predefined significance level (niveau = 0.001).
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A site modification 'P' has a predefined meaning.
To make predictions, single-nucleotide polymorphisms (SNPs) that meet a predefined statistical significance threshold of association with the trait are considered and a genetic score is constructed by adding the estimated effects of the alleles each individual carries for these SNPs (12).
Finally, a predefined metabolite database is mined for significant masses.
The percentage deductible is triggered by a predefined event.
We will be very carefully monitoring people under a predefined treatment protocol".
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CEO of Professional Science Editing for Scientists @ prosciediting.com