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Third, a predefined cut off for the GCPS was validated using an independent stage II cohort (N=216).
In contrast to URA, for simplicity, we are not taking continuous edge weights into account, but instead set all edge weights to 1 if they pass a predefined cut off δ (set to in the implementation).
Immunogenicity results are given as geometric mean concentrations (GMCs) of antibodies, proportions of infants with over 2- and 4-fold increases between different series, and as proportion of children achieving a predefined cut off value of ≥1.0 μg/ml of antibodies concentration.
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As part of our search for improved and simple diagnostic measures we have compared the performance of IP-10 and IL-2 with QFT-IT in a diagnostic setting without a gold standard for infection, we used predefined cut offs and criteria for positive test results and exposure gradient as indicators for infection.
Change in diagnostic confidence was calculated with a predefined cut-off (score 2); only scores 3 and 4 were seen as a change of diagnostic confidence.
Only three studies used a predefined cut-off value for determining whether the SUVr was amyloid-positive or amyloid-negative.
Children with values above a predefined cut-off were referred to the closest pediatric clinic for a small-intestinal biopsy [ 20, 21].
Using a predefined cut-off level is not a good practice as the optimal threshold will vary depending on which genes are evaluated.
In the context of gene correlation networks, a connection is typically defined if the correlation between a pair of genes is above a predefined cut-off value.
However, the categorization of the test-retest results as a function of a predefined cut-off point may be considered an inadequate simplification.
A patient's score is considered positive (predictive of liver toxicity) if its value is higher than or equal to a predefined cut-off value.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com