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In many cases, however, it is more convenient to knock down gene function in a specific tissue or at a precise stage of development.
We show here that HOP is expressed at a precise stage of epidermoid cell differentiation and its expression is lost in HNSSC, suggesting that HOP may be a general tumour suppressor gene involved in keratinocyte differentiation.
Recombination increases the copy number of gene by providing raw material for further functional innovations and diversification, and gene conversion, which principally homogenizes genes, can help insure the rapid synthesis of a gene product (protein) that may be required during a precise stage of cell cycle [ 68].
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However, in all the cases, the purpose was to dissect at least 13 LN, which should represent the cut-off for a precise staging of the tumor.
The histological evaluation of the central LN represents the quality standard of the lymphadenectomy and ensures a precise staging of the tumor, which decreases the shifting between tumor stages.
To elucidate the precise stage of arrest, we performed a direct comparison of the levels of curcumin-induced G2/M boundary and mitotic arrest in eight colorectal cancer lines (Caco-2, DLD-1, HCA-7, HCT116p53+/+, HCT116p53 /–, HCT116p21 /–, HT-29 and SW480).
The strength of an idea is what carries it through each precise stage of the creation process, from data gathering through structuring and designing.
Core Tb was monitored for precise stage of torpor and arousal by an automated telemetry system that measures and records core Tb every 10 min [ 19].
This variability likely relates to subtle differences in the precise stage of MPD at which individual junB-deficient animals were sacrificed, reflecting mouse-to-mouse variability in disease progression.
The precise stage of food handling at which contamination occurs is unknown.
Additionally, within the spermatocyte population, differential sensitivity was observed depending on the precise stage of meiotic maturation: dividing (stage XIV) and early pachytene (stages I-II) greater than late pachytene (stages VIII-XIII) greater than mid-pachytene (stages III-VII).
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