A more precise prognosis of the risk of relapse and a response prediction are needed.
Nevertheless, this system is limited in its ability to provide a precise prognosis: a large number of patients with similar or identical clinical and histopathological features has different clinical outcome, from being cured to death [ 4].
The first step toward the diagnosis of RD at the molecular level is genotyping; this allows a more precise prognosis of the possible future clinical evolution of RD, and it can be followed by genetic counseling.
The development of metabolomic technologies holds the promise to significantly improve diagnosis, unravel more appropriate therapeutic targets, and enable more precise prognosis of disease development.
The identification of the cells of origin from which cancer initially arises is of great importance, both for our understanding of the basic biology of tumours and for the translation of this knowledge to the prevention, treatment, and precise prognosis of the human disease (Visvader, 2011).
A comprehensive and precise prognosis scale of ischemic stroke still needs to be further developed [ 15].
The knowledge of all possible existing pleural tumour histotypes is important to perform an adequate differential diagnosis, provide a more precise prognosis and correct management of the patient.
Several researchers have studied the usefulness of tumour-associated antigens for primary diagnosis of OSCC, but no tumour markers have given a precise prediction of prognosis (Tsutsui et al, 1993; Krimmel et al, 1998).
Because no single factor can accurately predict prognosis, statistical prediction models to integrate the cumulative effects of individual prognostic factors are required for more precise prognosis predictions.
