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Finally, due to the aggregated nature of influenza exposure data, we are unable to define a precise effect period that might provide insights into whether this effect is driven by increased transmission, increased propensity for invasive disease, or increased colonization, though biological experiments described above strongly suggest that the latter may be important.
Also, to quantify a precise effect of a mediating variable (with narrow confidence limits) requires larger sample sizes than was available here.
To obtain a GWAS significant result, one needs: 1) a large effect size; 2) a precise effect estimate; or 3) luck.
Given the typically small number of events in HIV incidence studies, propensity score weighting permits adjustment for a large number of time-varying covariates that may be on confounding paths, resulting in a precise effect estimate.
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Anti-VEGF-antibodies may have a more precise effect in modulating the wound healing processes than anti metabolites and additionally may cause fewer side effects [ 11].
However, when appropriately conducted, large and small studies should theoretically give the same results, but with a more precise effect measure estimate in the larger ones [ 44].
In addition, longitudinal studies need to be encouraged in areas where studies are lacking to come up with a more precise effect.
However, when appropriately conducted, large and small studies should give, theoretically, the same results, with just a more precise effect measure estimate from the larger ones [ 29].
Finally, in nine out of 11 cohorts outcomes were ascertained from routine administrative databases, which could have led to a less precise effect estimate from misclassification of the outcome.
Another interesting extension could be an analysis of the precise effect of the location and number of DPs on costs.
And, of course, the precise effect of a Lib Dem meltdown will depend, seat by seat, on where its lost voters end up.
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