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In the context of whole human genome resequencing, on the order of a billion short reads are required to accurately resequence an individual genome, and this creates an unprecedented alignment problem of aligning this many reads to the reference human genome on a practical timescale of days.
The microbeam scan parameters and X-ray flux were chosen to be compatible with the acquisition of XANES and XEOL-XANES spectra from each pixel with acceptable statistics on a practical timescale.
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Many of these approaches require DNA motion through nanopores to be slowed by several orders of magnitude from its native translocation velocity so that the translocation times for individual nucleotides fall within practical timescales for detection.
There are theoretical reasons to believe that such evolutionary changes may be slow and, within practical timescales, even impossible to reverse (Law and Grey 1989; Dunlop et al. 2009).
What we can do is to set out what we believe to be a practical framework and a reasonable timescale for moving forward.
Such simulations via conventional molecular dynamics present a practical challenge due to the millions of atoms involved and the long timescales of the phenomena of interest.
Bertie Armstrong, the chief executive of the Scottish Fishermen's Federation, said: "Ministers seem to have taken care to agree upon a practical plan that would work for the fishing industry and we are pleased that a more realistic timescale for the implementation of a discards plan was agreed.
A practical Gaultier?
"It's a practical thing.
More in a practical way.
This was a practical necessity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com