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By the comparison of specific activity to recognize a positive candidate, a practical threshold is required.
They show that in this case the security increase with the code length, and they propose a practical threshold when type I error (originally detected as a forgery) and type II error (forgery detected as an original) are equal.
The existence of mechanisms leading to a dose response that is non-linear and has a practical threshold is increasingly recognized, not only for compounds that interact with non-DNA targets but also for DNA-reactive compounds [10].
The question of whether an absolute nonthreshold or a relative nonthreshold, i.e., a "practical" threshold specifically in the low-dose level, is present may not be answered even with the use of a prohibitively large number of wild-type mice.
To recognize a mutant of small improvement of catalytic capacity, specific activity calculated from total proteins in a lysate is an index better than activity concentration; a practical threshold for comparison to recognize a positive candidate can be the mean plus 1.4-fold SD of specific activities of the starting material.
For no less than 90% specificity to recognize the positive candidate in this uricase pair, the mean of specific activity plus 1.4-fold of the SD of the starting material can be a practical threshold (Additional file 1: sheet 2: ROC analysis of activity).
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After analyzing the finite precision influence on the training method of the EAPNN, the paper proposes an improved training method for the EAPNN with finite precision data and gives a practical threshold-value determination method.
Furthermore, even if noncarcinogens have putative thresholds, the combined effects from exposure to multiple HAPs with common health end points are likely to raise the cumulative dose response above any practical threshold levels (Clewell and Crump 2005).
But prospects for reclaiming some of that wasted energy have improved, now that scientists have devised a so-called thermoelectric material that crosses a key practical threshold for generating electricity from heat.
In this way it should be possible to establish if a real (or practical) threshold could be predicted for an adverse outcome.
A common assumption when extrapolating experimental animal data to estimated human responses at low doses is that if nonlinear or dose-transitional key events in an MOA are identified, then an actual or practical threshold exists.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com