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The phrase "a powerful negative effect" is correct and usable in written English.
It can be used when discussing the impact of an action, event, or phenomenon that has significant adverse consequences.
Example: "The new policy has a powerful negative effect on employee morale, leading to increased turnover rates."
Alternatives: "a significant detrimental impact" or "a strong adverse effect."
Exact(2)
Suppressing emotion has a powerful negative effect on your body called oxidative stress.
Perhaps unsurprisingly, the evidence to date suggests that armed conflict has a powerful negative effect on the mental health of civilians.
Similar(58)
"Rudeness has an incredibly powerful negative effect on the workplace". And, I believe, it has a negative effect on your soul.
"Rudeness has an incredibly powerful negative effect on the workplace," Foulk said.
"Rudeness has an incredibly powerful negative effect on the workplace".
The potential future clash between larger fiscal deficits and a low household saving rate could have powerful negative effects on both Japan and the global economy.
The strongest functional evidence for the role of G-actin in regulating the phosphatase activity of PPP1R15 comes from the various experiments in which manipulation of the actin cytoskeleton in living cells is shown to modulate eIF2α dephosphorylation.These correlate with powerful negative effects of depletion of G-actin on the stability of the endogenous PPP1R15-PP1 complex recovered from cells.
Fear is a powerful negative emotion.
Technology and innovation, warns Murray, is a powerful combination which, if managed incorrectly, can have a very negative effect, as data rarely shows the full picture.
Moving to a larger class had a negative effect.
Chernobyl had a profoundly negative effect on the population's thinking about nuclear power and provided a powerful stimulus to the growth of a Green (environmental) movement.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com