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In addition to revealing a potential deleterious effect of thiamethoxam systemic insecticides in wheat, our assays provide insight into the design and interpretation of toxicity assays involving systemic neonicotinoids and herbivores.
However pro-inflammatory markers independently correlate with disease progression (relative risk = 2.9), risk of amputation and 1-year mortality [11], suggesting a potential deleterious effect of the pro-inflammatory state observed in patients.
This observation allows us to hypothesize that in CR mouse lemurs a re-allocation of energy distribution to the brain could occur, thereby suppressing a potential deleterious effect of CR on hippocampus-dependent spatial memory task.
Such variants are thought to have a potential deleterious effect and have traditionally been associated with severe Mendelian diseases.
As expected, only a minority (< 10%%) of indels overlap with coding regions and have a potential deleterious effect on proteins (Additional file 4).
Indeed, despite the role of monocytes/macrophages in host defence, previous studies have suggested a potential deleterious effect of stroma-localised monocytes/macrophage, in relation with enhanced angiogenesis (Etoh et al, 2000; Hashimoto et al, 2000; Ueno et al, 2000b).
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In addition, any potential deleterious effect of delayed intubation in patients treated with NIV [41, 42] can be ruled out as time from ICU admission to intubation was not longer than in patients treated with HFNC alone.
While the new research found that intestinal bacteria in humans can also convert carnitine to TMAO, a vast body of previous clinical research (mentioned above) suggests that the beneficial effects of carnitine outweigh any potential deleterious effect of its breakdown product, TMAO.
A score threshold of ≤−2.0 was used to classify a variant as having potential deleterious effect.
It uses the phylogenetic relatedness among sequences and the physicochemical properties of amino acids to quantify the potential deleterious effect of a given amino acid change.
A recent study suggested that the potential deleterious effect of several T2D loci may be abolished or at least attenuated by higher physical activity levels or healthy lifestyle, whereas they may be augmented by low physical activity and dietary factors that are similar to a Western dietary pattern [ 146].
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