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T-cells are a potent type of white blood cell that destroy cells infected with microbes that they recognize as foreign.
Last year a group at the University of Minnesota found a way to guide human embryonic stem cells into becoming a potent type of white blood cell which destroys tumour cells.Actual clinical trials, too, are now under way.
Cilostazol is a potent type III phosphodiesterase inhibitor, approved as an anti-platelet aggregation agent.
BTV is a potent type I interferon inducer in mice and cattle [14], [16], [32].
As a potent type I collagenase [36], [37] it had been predicted that mice lacking the Mmp8 gene would show reduced PMN migration through collagenous matrices [34].
Therefore, we tried to examine the effect of exogenous expression of IRF7 under the assumption that IRF7 is a potent type I IFN inducer and capable of modulating the viral propagation in hepatocytes infected with HCV.
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Our results suggest that the combination of K3 CpG and cGAMP makes a potent type-1 adjuvant and a promising immunotherapeutic agent for cancer.
Thus, the combination of CpG ODN and a STING ligand may offer therapeutic application as a potent type-II IFN inducer.
It acts as a potent type-1 adjuvant, strongly inducing antibody responses, and CD4+ Th1 and CD8+ T cells, and as an antitumor agent that can efficiently suppress tumor growth in mouse tumor models of lymphoma and melanoma.
The combination of CpG ODN with cGAMP is a potent type-1 adjuvant, capable of inducing strong Th1-type responses, as demonstrated by enhanced antigen-specific IgG2c and IFN-γ production, as well as cytotoxic CD8+ T-cell responses.
Our findings that IL-12 and IFN-γ are significantly lower in T. gondii-infected PD-1−/− mice is intriguing, because a potent type-1 cytokine response is required for protection against several pathogens 2, 37, 38.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com