Deletion of Rab11a in cultured Rab11a fl/fl ;Villin-CreER + organoids through administrating tamoxifen elicited a less potent increase of IL-6 secretion (Fig 2K), suggesting that loss of Rab11a triggered an epithelial cell-intrinsic cytokine production.
It has previously been shown in primary brown adipocytes that NE induces a potent increase in GLUT1 mRNA and a decrease of GLUT4 mRNA (3).
On the other hand, coinjection of TO, at a dose equimolar to PA, produced similar albeit slightly less potent increase of AR42J tumor uptake (12.32 ± 3.66 % ID/g, P > 0.05).
However, compared with PA, TO and its prodrug Race induced less potent increases of tumor uptake, highlighting the significance of inhibitor type, administration route, and dose for implementing a first proof-of-principle study in human.
We recently showed potent increases of both ChoK and PtdCho-specific phospholipase C (PC-PLC) activities in EOC cells compared with non-tumoral counterparts [ 10, 11].
Typically, FF is applied for 30 150 pulses, in vitro, and results in an immediate and potent increase in the amplitude of the fEPSP (Salin et al. 1996; Toth et al. 2000; Nicoll and Schmitz 2005).
We (45) have previously demonstrated a potent interaction of increased intracellular magnesium with Kv channels in the vasculature.
Heparin-binding protein (HBP), a potent inducer of increased vascular permeability, is a potentially useful biomarker for predicting outcome in patients with severe infections.
Climate change is becoming a potent driver of increased risk in the form of extreme weather events and through slower-moving phenomena such as resource degradation and the erosion of territories and livelihoods.
The results presented above strongly suggest that InhA is a potent enzyme capable of increasing barrier permeability of HBMEC monolayers in vitro.
