The phrase "a potent hit" is correct and usable in written English.
It can be used to describe something that has a strong impact or effect, often in contexts related to drugs, music, or any impactful experience.
Example: "The new song by the artist is a potent hit, resonating deeply with listeners and topping the charts."
Alternatives: "a powerful impact" or "a strong effect".
The N.F.L. tries to restore calm with the most legitimate of testing programs intended to ensure that a potent hit is powered by effort, not chemistry.
Reading the stories one after another yields an illuminating historical sweep; dipping in can leave one reeling from a potent hit.
In 2005, using a 96-well cytoblot to screen the NCI diversity set for compounds that decrease the levels of STAT3 phosphorylation in MDA-MB-468 breast cancer cells, we identified Wit as a potent hit (Sun et al, 2005; Sun et al, 2008).
Most probably, RB loss represents a particularly potent hit for DCIS as it both relieves control over the cell cycle allowing for expansion of DCIS cells and promotes EMT-like processes that promote invasion.
In the quest for NPY5 receptor antagonists a virtual screening approach yielded a novel and potent hit class from a limited compound selection.
Based on the docking modes of the most potent hit compound, a series of derivatives are synthesized, characterized and biological assayed on the PLK1, EEF2K as well as breast cancer cell proliferation models.
The most potent hit was an inhibitor of transforming growth factor (TGF -β signaling.
The most potent hit, 6a, displayed an EC50 value of 0.87 μM, which is very close to that of quinacrine (0.4 μM).
Our efforts to develop an inhibitor for this highly validated target started with the identification of N- 3- 3,6-Dihydro-5- 3,4-dimethoxyphenyl -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl -phenyl -carbaminic acid-(3-(N- 3- 3,6-Dihydro-5- 3,4-dimethoxyphenyl -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl -phenyl -carbaminich-throughput screeN- 3- 3,6-Dihydro-5- 3,4-dimethoxyphenyl -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl -phenyl -carbaminic
The most potent hit shows inhibition in a non-competitive mode of action.
Compound 1 is the most potent hit against FABP4 with a selectivity of more than 144-fold preferences over human FABP3.
