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The results demonstrate a potent effect of riluzole against ischaemia-induced arrhythmias and ischaemic damage.
While our data demonstrates a potent effect of EDC (and E2-BSA) in inducing rapid nongenomic signaling, one should not construe that EDC only activates a nongenomic signaling pathway and is incapable of exerting genomic effects.
However, there is precedent for a potent effect of cytokines when delivered from biodegradable particles or cells interacting in close proximity.
Additionally, we saw a potent effect of circulating testosterone to decrease anxiety-like behavior in UCMS-exposed mice, consistent with prior evidence in the literature [ 98].
These results demonstrate a potent effect of the dominant inhibitory mutation of a p53 allele (p53+/R172H) on UVB-induced lincRNA-p21 transcript levels.
Therefore, these findings, showing a potent effect of anti-PD-1 and anti-PD-L1 in patient PBMCs, are highly relevant.
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Comedications known to have a potent effect on the PK of the drugs were avoided for safety reasons.
We also performed a cell-survival assay and observed that anti-ErbB2 immunoagents caused a potent effect on the survival of JIMT-1 and KPL-4 cells.
Nevertheless, in most cases both molecules synergistically modified the chondrocyte proteome, showing a potent effect on oxidative stress and modulation of energy production and metabolic pathways.
Notably, Luo and coworkers showed a more potent effect of herbimycin A, Src kinase-specific inhibitor, on the expression of MMP-1 and TIMP-1 compared to genistein [ 124], providing strong evidence for a critical role of Src kinases in modulating the expression levels of MMP-1 and TIMP-1 in macrophages in the presence of Co2+ and Cr3+ ions.
Primaquine given at 12 and 6 mg/kg completely blocked transmission to a secondary mouse population but did not exhibit a potent effect at doses of 1.25 and 0.25 mg/kg.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com