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At the latent stage of tuberculous infection, mycobacteria can penetrate into organs and tissues and persist there for decades before a possible activation of the tuberculous process followed by the development of active disease [ 1– 4].
To explore a possible activation of the plant defense system in the transgenic rice lines transformed with pUbI-DR-T, pUbI-D-T, and pUbI-R-T construct, the expression of the endogenous PR-1a gene was analyzed at the RNA level, without challenging with the pathogen.
Notably, these pathways are mostly enriched with up-regulated genes in cancer, suggesting a possible activation of these processes.
A possible activation of sphingomyelinase, that degrades sphingomyelin pools, provokes the plasmodial death.
A possible activation of Gsx transcription in later larval stages or in the adult sea star cannot be excluded.
These authors hypothesized a positive feedback loop between wtp53 and JNK/SAPK explaining a possible activation of p53 through JNK/SAPK, which then induces a p53-dependent apoptosis.
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A preliminary study reported possible activation of canonical Wnt signaling in high grade serous tumors [ 43] but another study did not support this suggestion [ 44].
3. Insertional mutagenesis due to vector integration into the genomic DNA and possible activation of a proto-oncogene is a recognized safety concern for gammaretroviral vectors.
Considering their identity as type-A response regulators, we tested the possible activation of both ZmTCRR-1 and -2 transcription by culturing developing kernels on media containing different hormones and performing either Northern Blot or qRT-PCR as detailed in Material and Methods.
"In some cases, maximum possible activation of a target gene is necessary to achieve a cellular or therapeutic effect.
The data suggest possible activation of a latent C-type virus by SC.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com