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This indicates a positive feedback model where MYC can reinforce its own expression from the PVT1 promoter in PVT1-MYC fusion tumours.
Treatment of human pluripotent cells with BMP-2 leads to the accumulation of transcripts for this factor consistent with a positive feedback model [9], but an increased level of BMP2 gene transcription in hES cells had not been reported.
All together, these data support a positive feedback model in which at the leading edge of motile cells ligand-engaged integrins trigger the formation of an R-Ras-GTP/RIN2/Rab5-GTP complex.
Based on our findings and the fact that synovial fibroblasts are among the major resources for IL-1β and TNF-α in the rheumatoid joints [ 31], we proposed a positive feedback model for SYN in RA development (Additional file 2).
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Altschuler et al. (2008) studied a related positive feedback model of Cdc42 with a homogeneous cytoplasmic pool of the inactive form.
The involvement of a potentially inhibitory receptor, 5HT1A, in consolidation suggests that a simple positive feedback model for consolidation is unlikely to be completely correct, and it highlights the fact that there is currently no information on the functional nature of the synapses between DPM neurons and MBs.
Similar to the positive feedback model, the negative factor model also has fast adaptability.
Compared to the standard positive feedback model (SF), however, the FF model displayed better tracking, but reduced polarization (Fig. 4B).
The steady states for the positive feedback model were considered in the text.
The data are convincing and the proposed H1 positive feedback model warrants future investigation in vivo.
Our prediction was that we would find little genetic variation for tolerance if the simple positive feedback model is true, but that negative feedback loops would result in considerable variation for resistance.
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