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Tregs constitute a population responsible for dominant tolerance to self-tissues in the immune system.
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Typically they are referred to as suture mesenchymal cells and are a heterogeneous population responsible for driving the rapid skull growth that occurs in utero and postnatally.
IDUs were postulated as a main population responsible for the generation of so many URFs since they often injected drugs together across the border and shared needles/syringes.
This would still support the utility of mTert-GFP expression in identifying a population responsible, at least in part, for cardiomyocyte development and regeneration.
There is increasing evidence for tumour stem cells in brain tumours (reviewed in [ 11]) and it is intriguing to speculate whether a stem cell population, responsible for perpetuating tumour growth, might reside in this fraction.
Our study identifies Lrig1-expressing cells in the upper isthmus as a highly proliferative SC population responsible for maintenance of the infundibulum.
Bhang and colleagues have recently traced the emergence of erlotinib resistance in a model of lung adenocarcinoma, identifying a pre-existing MET-amplified clonal population responsible for in vitro recurrence (Bhang et al. 2015).
This will have implications for the replicative fitness of the viral population responsible for founding a new infection.
CSCs represent into the tumor, a small subset of the cancerous population responsible for tumor initiation and growth.
We found 9 pathogenic mutations in RP1 among which one (p.Ser542* in CIC00445) was already reported by Avila-Fernandez et al. [ 12] as a founder nonsense mutation in the Spanish population, responsible for 4.5% of arRCD.
Keeping in mind the pathogenic, mechanistic, and pathological heterogeneity of MS, our findings suggest that CD8+ T cells, working via a perforin-dependent mechanism, are the primary effector population responsible for injury and loss of demyelinated axons.
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