The observed heterogeneity shows that although a given concentration of quorum signal may determine the average light output from a population of cells, it provides far weaker control over the luminescence output of each individual cell.
The distribution of Hsp104-GFP in a population of [ PSI + ]Weak cells that had been exposed to 40°C was very complex in contrast to the normal distribution of Hsp104-GFP at 30°C, suggesting that subpopulations of cells were differentially retaining the chaperone.
Papathanasiou et al. [ 34], in a population of Greek young adults found weaker ICC (0.76) for moderate physical activity compared to walking (ICC = 0.78), vigorous (ICC = 0.88) and total physical activity (ICC = 0.92) on the Greek version of IPAQ-SF.
A larger number of LGMD2C patients would be required to determine the reliability properties of the measurement in this population of weak subjects.
It has been reported that more than 200 genes may be involved in the endospore formation process (Madigan et al., 2000), but the large population of weak pairwise association COGs in the extracted rules suggest that many of endospore-relevant proteins may be used in other biological functions as well.
Patients with chronic HBV infections are usually characterized by a population of exhausted T cells, which have weak virus-specific T-cell responses during chronic HBV infection, impeding the clearance of virus and recovery from hepatitis.
Moreover, another major subset of the DC family was identified as a population of cells morphologically resembled plasma cells with weak antigen presentation ability, but, upon exposure to viral stimuli, they can produce large amounts of type-I interferon.
For example, a population of 80% unfolded apo DHFR with very weak ligand binding would lead to a contribution to cooperativity of up to −0.95 kcal mol−1.
Using this protocol (summarized in Figure 1A; see Experimental Procedures for details), we were able to identify a population of large, strongly GFP-positive cells (NBs) and less-defined populations of small cells with weaker GFP signal (differentiated cells; Figure 1A).
However, the finding in the general population of a weak risk-reducing effect of aspirin in patients at lower baseline cardiovascular risk 3 was not verified in our patients with type 2 diabetes.
