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(A) Population coverage distribution.
Overall, the alleles addressed by the novel platform provided a population coverage of 91.7%, 81.0%, and 94.0% in the HLA-A,-B, and -C loci, respectively.
These records were converted to a population coverage based on the total number of (elderly) inhabitants within the intervention municipality.
Such communities do not normally benefit from herd immunity which generally requires a population coverage of more than 90% for measles immunization.
24 26 The networks in Belgium and The Netherlands were nationwide with a population coverage of 1.8% and 0.8% in 2009 and 1.5% and 0.8% in 2010, respectively.
The analysis was conducted on 12 HLA supertypes, representing ~120 human MHC alleles and providing a population coverage of 99.8% worldwide.
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The principal aims of the 1997 health insurance reform were: a) to achieve a wider population coverage with basic medical care benefits across all the groups participating in the scheme; and b) to control the oversupply and the over-utilisation of health care through setting mechanisms to alter the behaviour of health service users and providers [ 1].
Finally since the PC strategy has a lower population coverage than the first two, we formulated a fourth strategy that combines it with a more general vaccine distribution to attain a final 47% coverage.
In conclusion, H56 vaccine is predicted to have a promising population coverage in South Africa; this study demonstrates the utility of integrating comparative genomics and bioinformatics in bridging animal and clinical studies of novel TB vaccines.
This kind of structure-based screening helps overcome the barriers of insufficient training data and lack of peptide binding motifs, especially for MHC-II alleles, thereby cutting down the lead time involved in experimental vaccine development methods, resulting in production of effective and highly specific peptide vaccines with a wide population coverage.
One of the main benefits of using general practice databases for disease surveillance is the ability to access data from large patient populations across a wide population coverage.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com