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"Secondly it has a poor impact on an individual's well-being.
The currently available iron chelators have poor efficacy in depleting the macrophage iron stores and, therefore, have a poor impact on the infection.
Antifungal treatment was started in 64 % of PIPA cases, with a poor impact on the overall outcome.
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Many early works investigating the CD44s gene and its splice variants report a poorer impact on survival time in patients with increased expression levels of the gene or protein (Mulder et al, 1994; Wielenga et al, 1998).
It only produces poor impact on brain with no progress.
In the final Cox model for multivariate analysis (Table 3 > -wrap-foot>), presence of ascitis (P=0.008) and HER-2 overexpression (P=0.001) both retained a poor prognostic impact on progression-free survival.
These mutations, which affect distinct residues in CSF3R as compared with CNL, are frequently associated with mutations in the ASXL1 gene and have a poor prognostic impact on overall and acute myeloid leukemia (AML -free survivAML -free
Thus, despite its significant influence on VEGF-A expression in HNSCC, PAIP2 is insufficient to confer to VEGF-A its impact on poor prognosis.
We hypothesise that other factors, which also regulate VEGF-A expression, will be responsible of VEGF-A impact on poor prognosis.
MDS subgroup analysis revealed that the poor impact of a U2AF1 mutation on OS was only demonstrated in the lower risk groups (very low and low) defined by IPSS-R (P = 0.035; Fig. 3a).
The level of TAMs has been indicated to have poor prognostic impact on a number of cancers, including breast cancer and follicular lymphomas (Leek et al, 1996; Dave et al, 2004; Shunyakov et al, 2004; Sanchez-Aguilera et al, 2006).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com