The expressions of TGFB1, CDH1, and CDH2 of the NTF were up-regulated after co-culture with JHH-6, a poor-differentiated HCC cell line.
Furthermore, higher expression of miR-24 was observed in the HCCLM3 (a kind of poor differentiated HCC cells with high infiltrating capacity) cells compared to in the HepG2 (a kind of good differentiated HCC cells with low infiltrating capacity).
For example, in well differentiated tumours patients' survival could be separated in longer than study duration in comparison to 59.67 months as well as in poor differentiated tumours with a distinction of 47.0 vs 11.00 months, as is evident from Figure 5.
The relevant clinical parameters, including age, gender, alcohol use, smoking habits, original primary tumor site and pathology stage, are listed in Table 2. Abbreviations: PD, poor differentiated; WD, well differentiated; MOD, moderate differentiated.
They demonstrated that miRNA expression profile was able to put together different tumor samples sharing the same development linage and to classify poor differentiated tumors based on their origins with a better correlation than mRNA profile performed in the same samples.
In one case (i.e. poor differentiated tumour) oesophageal EUS performed 2 months after the treatment suggested a stable disease (uT3) when endoscopy was normal.
Nodules resulted malignant (n = 18) included 15 thyroid cancers (papillary thyroid cancer = 13, poor differentiated thyroid cancer n = 1, medullary thyroid cancer = 1), 2 metastases from bladder cancer and breast cancer respectively, and 1 lymphoma.
Wnt signaling is important for CSC self-renewal, for example, Wnt/β-catenin signaling is activated in poor differentiated basal-like breast cancer with worse overall survival (Khramtsov et al., 2010).
WD, well differentiated; MD, moderate differentiated; PD, poor differentiated; CCRT, concurrent chemoradiation therapy; CI, confidence interval.
Twenty-nine tumours were classified as well differentiated, and 7 as poor differentiated.
