Sentence examples for a polymorphic variant from inspiring English sources

In particular, involvement of a polymorphic variant of desmoglein 1 gene was shown to be associated with pemphigus foliaceus and to interact in an epistatic manner with MHC class II genes to contribute to the autoimmune process.

Interestingly, it has been shown a positive allelic and genotypic association between a polymorphic variant in NOTCH3 (namely, rs 1043994, c.684G>A) and MA in two independent population [55].

Historically, there has been uncertainty as to whether the European species known as Battarrea stevenii is a unique species or merely a polymorphic variant of B. phalloides.

Furthermore, a polymorphic variant of the human ERRα promoter has been associated with variable bone mineral density (BMD) in premenopausal women [23].

In conclusion, we show that a polymorphic variant within the ABAT gene is associated with GERD and that ABAT inhibition leads to a reduction of TLESRs and acid reflux events.

In another independent case-control study, a polymorphic variant in human MDM4 was only found to be associated with an accelerated age of onset of estrogen receptor negative breast cancer [16].

Control cell lines used for the calcium studies were the parental embryonic stem cell line ES-I and a cybrid (Cy1-I) with a benign polymorphic variant (m.9821Adel) in the mitochondrial transfer RNA for arginine (Mttr).

Using a reporter gene assay, Jurutka et al. also demonstrated that a natural polymorphic variant of human VDR, resulting from missing a FokI restriction site, which lacks the first three amino acids, interacted more efficiently with the human basal transcription factor IIB (TFIIB).

It was due to their polymorphic nature that it could easily be conceived that a specific polymorphic variant could alter drug metabolism and cause a rare form of DILI.

The variable success of candidate malaria vaccines may be due to the high degree of diversity of P. falciparum antigens [4] and a variant-specific immune response [5], [6], particularly as most vaccines are formulated with a single polymorphic variant.

We also identified a novel polymorphic variant (398T/C, I133T) of the CSNK2A1P gene and showed that the 398T allele is selectively amplified over the 398C allele in 101 non-small cell lung cancer tissue samples compared to those in 48 normal controls (p = 0.013<0.05).