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How are molecular chaperones able to assist correct folding of a plethora of structurally divergent proteins?
The hERG channel is blocked by a plethora of structurally diverse compounds, including many marketed drugs, some of which, such as terfenadine and cisapride, have been withdrawn from the market due to this unwanted activity [ 1- 3].
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It is therefore reasonable to hypothesize that in specific cellular environments in the nervous and lymphoreticular systems, interaction with a common molecular partner might promote the selection and enrichment of thermodynamically and conformationally unique PrP morphotypes among the plethora of structurally distinct species predicted by the high-dimensional PrP folding energy landscape [ 11].
These seemingly conflicting structural properties of the active center are demonstrated through combination of structural methods with kinetic studies of the enzyme and its mutant derivatives with plethora of structurally diverse ligands and in particular with series of stereoselective covalent and noncovalent AChE ligands.
The cytochrome P450 enzyme CYP1A2 plays a main role in the metabolism of a variety of structurally unrelated compounds, including a broad range of different drugs, and its activity is widely modulated by a plethora of inducer/inhibitor molecules.
"Plethora", for a plethora of reasons.
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"I've got a plethora of problems.
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