The phrase "a plethora of modifications" is correct and usable in written English.
It can be used when describing a large number of changes or adjustments made to something, such as a document, project, or system.
Example: "The software update included a plethora of modifications aimed at improving user experience and functionality."
Alternatives: "an abundance of changes" or "a multitude of adjustments".
Systematic analysis of histone modifications has revealed a plethora of posttranslational modifications that mediate changes in chromatin structure and gene expression.
As mentioned above, histone modifications include a plethora of post-translational modifications.
This allelic methylation profile is associated with a plethora of histone tail modifications that orchestrates higher order chromatin interactions.
Oestrogen receptor activity is also regulated by a plethora of post-translational modifications including phosphorylation, acetylation and methylation (Le Romancer et al, 2011).
Ovalbumin is decorated by a plethora of post-translational modifications (PTMs), including N-terminal acetylation (G1), phosphorylation (most prominent at S68 and S344), and extensive glycosylation (N292) and contains a disulfide bridge (C73-Cys120).
Within this framework, epigenetic mechanisms alter the accessibility of DNA by modification or rearrangement of nucleosomes, as well as through a plethora of post-translational chemical modifications of chromatin proteins such as histones and DNA itself (see below).
Histone tails have a plethora of different post-translational modifications, which are located differently in "open" and "closed" parts of genomes.
Functionally, methylation of lysine or arginine residues on histone tails, similar to a plethora of other post-translational histone modifications (e.g., phosphorylation, acetylation, SUMOylation, ubiquitylation), has been shown to recruit protein complexes affecting target gene expression at the transcriptional level [11] [12].
For example, a plethora of antibodies recognizing specific histone modifications has been developed and used in chromatin immunoprecipitation (ChIP) assays for studying the local enrichment of histone PTMs at specific loci [ 22, 23].
