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Basically, this holds that after any major innovation comes a phase of selection and improvement, followed by a shake-out among suppliers, and finally a convergence on a single solution that is then adopted wholesale by the remaining participants.
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Thus, a phase of purifying selection would follow an initial phase of positive selection.
Proposed models can serve by the theoretical basis of the quantitative characteristics of an estimation of activity of astronauts in conditions of the emotional factors at a phase of their selection.
It could be due to a phase of positive selection on a new function, or to neutral evolution of a functionless sequence.
An extensive analysis of single gene duplicates from a number of species reveals that duplicates typically undergo a phase of relaxed selection or even accelerated evolution at replacement sites and progressively become more constrained as they age [ 23].
The proposed two-phase approach permits a second phase of selection to be focused on the needs of the application at the time that the infrastructure is being deployed.
During the early stage, the duplicates generally evolve under purifying selection, with a phase of relaxed selective constraint immediately after the duplication [ 51, 52].
The beginning of the selection process constituted a phase of 23 generations of selection for high protein content of the carcass at the age of 60 days.
Those who complete all phases of selection are rewarded with a transfer to an operational squadron.
The Olympian, who was named in a second phase of selections in early May, has now formally withdrawn from Glasgow 2014 because of a hip problem.
This type of "global" approach must be implemented in both phases of the clinical pathway: (a) in the initial phase of selection of the active substance and administration route; and (b) in the subsequent phases, characterized by the achievement of the optimal daily dosage, even in case of switching due to inefficacy, intolerance, or difficulty in administration.
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