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Therefore, a PET data set comprising N voxels can be represented by an N×1 vector x=(x 1…x N ) whose elements are real-valued and positive, x n ≥0, n=1,…,N.
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An illustration is provided using a sequential PET data set acquired to study the effect of d-amphetamine on cerebral blood flow in baboons.
A clinical FDG head PET/CT/MR dataset was used to simulate a 40M-count PET data acquisition with TOF resolution of 580 ps.
Respiratory compensated (RC-liver) PET data (a) demonstrates a lesion in segment 2/4A of the liver, which corresponds with a hepatobiliary phase (HBP) hypointense lesion on MR (b and c).
Using a navigated acquisition, the lesion is aligned with the PET data (a and b), as compared to a breath-held acquisition where the lesion is displaced inferiorly with respect to the PET acquisition (a and c) Fig. 6 A 57-year-old female with metastatic neuroendocrine tumor to the liver, the mediastinum, and lung (a).
When the contrast agent is injected into the body, an overcorrection of PET data tends to occur and could potentially mimic 18FDG accumulation.
Contrast-enhanced MRI information (e.g. on perfusion and blood flow) can be used in the pharmacokinetic modelling of the PET data, resulting in an improvement in PET reconstruction and data analysis.
The simulated data where created by modifications to a number of clinical PET data sets.
To reduce these MRI-SNR degradations, we propose "RESCUE", a MR-synchronously gated PET data acquisition technique.
A wide variety of PET data analysis techniques can easily be adopted in the workflow solution to deal with tracer studies using different radiolabeled compound and imaging protocol.
For attenuation correction of PET data, a low-dose CT scan (30 mAs) was acquired before the contrast-enhanced multiphase CT protocol.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com