Integrated prophages can comprise up to 10 20% of the chromosome size [ 25], and additions of such an amount of non-periodic DNA into a chromosome with otherwise persistent sequence periodicity could decrease the values of the Max2, Max3, and MaxMax indices.
If hi is true, then for a persistent enough sequence of observations (i.e., if proper detectors can be built and trillions of protons kept under observation for long enough), eventually a proton decay will almost surely be detected.
It is possible that rigid sections of the nucleoid are less susceptible to phage integration, and chromosomes with persistent sequence periodicity are (partially) protected from phage integration.
Moreover, chromosomes that contain prophages tend to have weaker or less persistent sequence periodicity, suggesting that the periodicity and concomitant DNA curvature could also play a role in protecting the chromosome from phage integration.
Analyses of prokaryotic gene repertoires revealed a persistent bias of disruptive sequence repeats towards gene termini, potentially to curtail the metabolic costs or toxicity associated with transcribing and (or) translating non-functional genes [ 13].
This microsatellite sequence forms a persistent DNA-RNA hybrid that initiates replication of the mtDNA heavy strand [ 36].
Indices of this type then become a persistent resource against which query sequences of the same species can be assessed for their repeat content.
Perturbations in the spatial distribution of inflammatory cells, changes in the type and magnitude of the inflammatory cell infiltrate, and disrupted temporal sequence, result in a persistent rather than resolved inflammatory phase [ 5] and functional impairment of skeletal muscle [ 6].
Some studies have aimed to minimize this possibility by excluding events within the first 1 2 years from analysis; the demonstration of a persistent relationship thereby supporting a temporal sequence consistent with causality 1. RHR is determined by sinus node activity, which is largely influenced by the interaction of sympathetic and vagal activity.
A persistent and temporal genetic drift in NoV capsid sequences was also reported worldwide [17], [27], [32] [35].
Proteolysis of mutant huntingtin releases a persistent N-terminal fragment comprising the first 100 150 residues with the expanded polyglutamine sequence.
