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Similarly, Burkholderia pseudomallei, the causative agent of meliodosis, can be carried asymptomatically for extended periods before illness onset, posing a persistent exposure risk for persons working with imported nonhuman primates from regions to which meliodosis is endemic (7 ).
Concerns have been mounting about the safety of a persistent exposure to folic acid that results in the circulation of unmetabolized folic acid (8), including the potential for masking vitamin B-12 deficiency (9) and the acceleration of cognitive decline in the elderly with a low vitamin B-12 status (10, 11).
More interestingly, high glucose seems not even to be an obstacle for the improvement of MSC-based therapies [ 36], in spite of the fact that a persistent exposure to elevated levels of glucose can be responsible of the detrimental effects caused by hyperglycemia such as the increased levels of reactive oxygen species and the production of advance glycated end products known as AGEs [ 37– 40].
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These results suggest that a similar persistent exposure to immunogenic epitopes for several days might be useful in development of component vaccines as well.
In most neurons, the frequency and amplitude of the transient Ca2+ peaks increased and then adapted after about one minute, possibly a consequence of persistent exposure to yeast.
Dietary habits based on a frequent and persistent exposure to meals with high intake of salt/animal fat and trans fat/sugar-sweetened drinks stresses our immune/metabolic system and the subsequent possible failure of homeostasis may lead to immune and metabolic disorders of diverse nature.
Indeed, enduring neuropathic or inflammatory pain is a well-characterized pathophysiological condition in which a direct parallel between persistent exposure to excitatory/inflammatory neurotransmitters and the increased excitability of spinal post-synaptic neurons has been clearly shown [ 8– 11].
Table 4 shows results of a multivariate analysis when persistent exposure, higher baseline sputum eosinophil levels and baseline FEV1 (% of predicted) were used as independent variables.
In 280 patients with red cedar asthma with persistent exposure, a greater rate of decline in FEV1 was observed in comparison with asymptomatic sawmill workers.
We make a series of suggestions for the design of susceptibility studies focusing on persistent exposure to a specific pesticide in genetically defined population subsets of workers and gardeners within a geographically defined area.
The squamous epithelium goes into irreversible change, including epithelial dysplasia and oral intra-epithelial neoplasia/carcinoma in-situ (OIN/CIS) [2], finally resulting in the development of invasive carcinoma through the accumulation of genetic abnormalities caused by persistent exposure to a carcinogen.
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