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Pulmonary arterial hypertension (PAH) is a fatal disease characterized by a persistent elevation of pulmonary artery pressure and ventricular hypertrophy.
This is consistent with our results that presence of flagellin in culture media of porcine corneas resulted in a persistent elevation of EGFR signaling (detectable at 48 h), leading to enhanced epithelial wound closure.
For the first time in mice, we found that temporary feeding of the obesigenic diets resulted in a persistent elevation of body weight and fat when compared to mice that never received the obesigenic diets.
Our results illustrate the importance of considering the history of energy imbalance in determining body weight and that a persistent elevation of body weight after removal of obesigenic diets can result from very small increases of energy intake.
Of note, the diabetic group displayed a persistent elevation of glucose from childhood through adulthood.
As cimes promoted a persistent elevation of intracellular calcium concentration, activation of calpain appeared quite likely.
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57 A similar persistent elevation of the cryptococcal disease burden since the 1990s has been described from MLICs in Southeast Asia 56, 58 and Latin America.
When dealing with a young hypertensive patient, it is unlikely that an expected persistent elevation of total and LDL cholesterol over decades may be beneficial.
This difference may be due to a species' dependant persistent elevation of P4 throughout diestrus leading to a pseudopregnant state [14].
In sharp contrast, we documented that CLP mice pre-conditioned with priming SL dose (5 ng/kg body weight) LPS had a significant and persistent elevation of plasma levels of TNF-α and KC (CXCL1) as compared to other two groups.
Joint fluid also showed an initial and persistent elevation of the neoepitope Col2CTx in the C-telopeptide of type II collagen, indicating digestion of mature, crosslinked collagen by a MMP.
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