The phrase "a persistent and significant" is correct and usable in written English.
It can be used to describe something that is both ongoing and important in a particular context.
Example: "The study revealed a persistent and significant increase in temperature over the last decade."
Alternatives: "a continual and notable" or "an ongoing and important".
The authorities are also investigating Wal-Mart, which was the subject of a New York Times investigation last year that showed how bribery played a persistent and significant role in the retailer's rapid growth in Mexico.
Ventilator-associated events (VAE), reflecting worsening oxygenation, are defined as a persistent and significant increase in FiO2 or PEEP level after a period of stability on the ventilator.
This evidence implies that the underlying reason for lower returns to foreign schooling and a persistent and significant occupational mismatch may not be the postarrival difficulties involving the recognition of immigrants' foreign credentials but rather the lower quality of those credentials.
It is well known that there is a persistent and significant reduction in RV long-axis velocities after cardiac surgery.
However, for the 2 mg dose, by 3 months (just prior to the next injection), there was a persistent and significant reduction in these markers of bone resorption compared with placebo of about 40% (p < 0.003).
Using CE-MS analysis of urine in all available samples (a subset of 22 of these patients) we were able to demonstrate a persistent and significant changes of the previously established proteomic CKD classifier [ 20] towards "healthy".
Pain associated with vaso-occlusion in sickle cell disease (SCD) is a life-long persistent and significant problem, which has profound medical, psychological and social implications for affected patients and their families.
They are no longer viewed as a temporary solution to persistent and significant health workforce challenges or a second-best service delivery approach [ 5, 6].
A statement by the subcommittee said recent deaths "point to a persistent and widespread problem, raising significant questions about the sport and its governance".
In samples with persistent and significant ADC increases at 20 min, the percentage change in mean ADC 1 5 min after sonication was significantly greater than in samples without persistent ADC changes (11.3 ± 4.9% versus 5.8 ± 3.4%, p = 0.009).
Health inequities for Māori, the indigenous people of New Zealand, are persistent and significant, and are particularly evident around maternal and infant health [ 1].
