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The phrase "a pernicious effect" is correct and usable in written English.
It can be used to describe something that has a harmful or damaging impact on someone or something. Example: The new fad diet has had a pernicious effect on young girls, leading to unhealthy attitudes towards food and body image.
Exact(26)
Still, the act also had a pernicious effect.
This moral panic, masquerading as vigilant protection, has a pernicious effect upon society.
It is worse than that: it actually has a pernicious effect.
But telling students that they must sound smart in order to succeed has a pernicious effect as well.
"It has a pernicious effect on our politics and on governing, because to govern, you need a mandate.
This is hardly a surprise, but it can have a pernicious effect: auditors become more and more reliant on big customers.
Similar(34)
Labour's disastrous Transforming Community Services strategy of 2009 had a particularly pernicious effect – a policy more concerned with meeting an artificial deadline for purchaser-provider purity than developing high quality services.
The exclusion of transgender boys had a similarly pernicious effect.
High turnover has a potentially pernicious effect because it makes it easier for terrorists to get airport jobs.
This has a particularly pernicious effect in protracted crises such as in South Sudan or eastern DRC, where humanitarian work resembles a 20-year series of one-year projects.
Such arguments also have a further, pernicious effect: they imply that the right basis for making ecologically-sensitive decisions is according to what makes business sense.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com