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Nevertheless, how BIO could have a permissive effect on insulin action in insulin-resistant myotubes remains to be determined.
Since the use of an attenuated Brucella strain more easily reveals a permissive effect connected with macrophage dysfunction [40], we first reexamined the in vivo role of TLR4 using C3H/HeJ mice and the cognate WT strain infected with attenuated B. abortus S19.
Glucocorticoids have a permissive effect on the synthesis of catecholamines and vasoactive peptides [ 20].
This suppression has a permissive effect on the production of another subset of T-helper cells called Th2 cells [ 50].
Data showing enhanced disease in TLR9-deleted mice may reflect a permissive effect for TLR7-activated pathways.
It may be that some of these factors provide a "permissive" effect on GCLRP-mediated activation of the monocytes.
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To determine if senescence has a similarly permissive effect on xenograft tumour establishment, mice were injected with 1 × 10 LNCaP cells either alone, with 50% Matrigel or with 1 × 10 senescent LNCaP cells (n=5 in each group).
These figures demonstrate the specific effect of the verum included in the meta-analysis, and their amplitude suggests that a genuine placebo effect does exist, mostly when a permissive outcome is chosen.
Similarly, cortisol plays an important role in maintaining of vascular tone and myocardial contractility and has an important permissive effect on the action of catecholamine on vascular smooth muscle [ 22].
SHH acts at a long-range and has a long-term permissive effect on hairy2, whereas the FGF effect is of a short-term, short-range instructive nature.
This permissive effect correlates with an increased expression of Fas receptor and a decreased expression of several endogenous inhibitors of apoptosis (IAPs).
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