Sentence examples for a perfect complementarity from inspiring English sources
The slicer activity of Argonaute requires a perfect complementarity around the cleavage site of the guide-target duplex [ 25].
Masking uses oligonucleotides that modulate a specific miRNA target, since they display a perfect complementarity to the target miR [ 58, 63].
The docking study presented in this paper suggests a perfect complementarity between the PIR1 deep catalytic cleft and the triphosphate tail of RNA.
However, the strong RBS in the 5′ UTR of gfp in pXG-1 (Urban and Vogel, 2007) shows a perfect complementarity to part of the conserved Yfr1 motif.
In metazoan, the situation is more complex since a perfect complementarity is not necessary for a miRNA to recognize its targets.
Importantly, one of the genes was integrin α5 (ITG α5), whose 3′-UTR sequence had a perfect complementarity with the seed sequence of miR-205.
Therefore, we searched for miR target sequences in the TEF gene using the TargetScan and PicTar prediction programs [18], [19], and identified a highly conserved seed sequence for miR-125a and miR-125b homologs within the 3'-untranslated region of TEF that exhibit an almost perfect complementarity with both miRs (the interaction between miR-125b and human TEF is shown in Figure 3A).
These 13 ISs (IS Kra2, 4, 5 and 6; IS Casp2 and 3, IS Lfe1 and 2; IS Hhy1; IS Acce1; IS Tvi1; IS Uncu20; and IS Desp4) are characterized by an almost perfect complementarity (83 100%) between the right and left IRs.
The most important requirement for microRNA base pairing with an mRNA target in animal cells is a continuous and perfect complementarity of microRNA nucleotides 2 8, known as the seed region, to the 3' UTR of the target mRNA [19].
When an miRNA and an mRNA exhibit perfect complementarity, the target mRNA is cleaved by RISC.
A perfect, or near perfect, complementarity between an miRNA and its target mRNA, which is a peculiar feature of plant miRNAs, provides a powerful tool for the identification of target genes through BLAST analysis of mature miRNA sequences against EST sequences.
