In contrast, levels of surfactant protein-C (SPC) present in alveolar cells (Figure 3b), demonstrated only minimal down-regulation (1.2 fold down-regulated, p = 0.18) at day 1, and transcript levels returned to control levels at days 3 and 7, thus confirming a pattern of injury specific to the airway epithelium and not the parenchymal tissue.
A pattern of injury combinations and spatial aggregation of injuries was also found.
While these biopsy features define a pattern of injury, they do not define the underlying etiology [ 1].
The histopathology, rather, presents a pattern of injury that in turn allows the treating physicians to seek out an etiology behind that pattern.
While IF/TA has come to replace CAN [ 1], it is still not a specific disease, but a pattern of injury that has many underlying causes.
Furthermore, a pattern of injury that includes thalamic volume loss and microstructural change in white matter is associated with neurodevelopmental outcome in early childhood (Boardman et al. 2010).
Rather than a single disease entity, FSGS describes a pattern of injury seen in kidney damage secondary to a number of identifiable primary causes but also seen as an idiopathic, isolated finding.
For the purposes of the current analysis, a biopsy was eligible for inclusion if it was obtained within 6 months of the protocol-defined DILI onset date and was adequate, in the pathologist's opinion, to assign a pattern of injury.
38 It thus appears that the transmission of explosive blast shock pressure waves into the brain injures the hippocampus regionally and has greater effects on visual than verbal memory, a pattern of injury that results in functional memory differences from that in PTSD.
