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By searching genome databases for genes with a pattern of DNA letters similar to those of known TNF family members, the researchers fished out the new gene.
The finding was startling because no human DNA of such antiquity -- at least 30,000 years old -- had been recovered and because it showed a pattern of DNA that was quite different from that of modern humans.
The fpg-modified comet assay revealed that the transfection with PKCδ-DN induced a pattern of DNA damage similar to that observed in EV-transfected cells (0.0005±0.0001 in untreated and in BSO-treated PKCδ-DN cells and 8.532±4.658 in etoposide exposed cells).
Subtelomeric sequences often display a pattern of DNA repeat blocks, linker regions and sometimes genes.
A position weight matrix (also called position specific scoring matrix, PSSM) infers a pattern of DNA segment and is widely applied in searching TFBSs [ 18– 218.
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Such a pattern of "partial" DNA methylation can be represented by genomic patterns of CpG depletion, which is a good proxy for the level of DNA methylation.
In a recent paper in Nature, a team led by Jeffrey Gordon, a microbiologist at Washington University, reports that each of us has, so to speak, a viral identity — a pattern of viral DNA that is highly stable and highly distinct, even among closely related humans.
Further experiments showed that each iPS cell line had a different pattern of DNA methylation, a molecular coating of the DNA that turns genes on or off in the cell.
Comparison with data from the CEPH sample indicates not only a similar pattern of association results, but also a similar pattern of DNA methylation levels across the DRD4 CpG sites.
This study suggests that obligate fungal endosymbionts in insects undergo a different pattern of DNA sequence evolution than obligate bacterial endosymbionts when establishing a symbiotic relationship.
This showed a complex pattern of DNA binding activities but only the pre-B cells contained a complex reacting to the addition of anti Pu.1 anti-sera.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com