Here, we constructed a synthetic pathway composed of acetyl-CoA acetyl transferase (encoded by thl), acetoacetyl-CoA transferase (encoded by atoAD), acetoacetate decarboxylase (encoded by adc) and secondary alcohol dehydrogenase (encoded by adh) in Synechococcus elongatus strain PCC 7942 to produce isopropanol.
The endocannabinoid system (ECS) is a signalling pathway composed of at least two G-protein coupled receptors (cannabinoid (CB 1 and CB2) and their endogenous ligands, involved in functions ranging from movement control to analgesia and emotional-affecting roles.
Given Properties 1 and 2, and Deduction 4, an extreme pathway composed of more than two reactions can never contain a forward-reverse reaction pair.
Efforts to broaden the substrate spectrum of S. cerevisiae beyond glucose include the use of an intracellular cellobiose-degrading pathway composed of a cellodextrin transporter and an intracellular β-glucosidase [ 5].
We previously constructed a synthetic metabolic pathway composed of genes from Escherichia coli, Saccharomyces cerevisiae, and Klebsiella pneumoniae.
An in silico evaluation of different process alternatives was performed, taking as an example a multi-enzymatic system for high-yield production of hydrogen from biomass catalyzed by a synthetic metabolic pathway composed of 13 enzymes.
This is a very large pathway composed of 166 genes and 2650 SNPs.
These findings unraveled a heretofore unknown pathway composed of mir-30d, foxo3a, ARC and caspase-1 that regulates myocardial pyroptosis.
Our data define a new signaling pathway composed of Arfaptin, Arl1, and Garz, required for the generation of normal synapse morphology.
For this purpose, we exploited the SPIKE database of manually curated pathway maps, where each map describes a specific cellular pathway composed of tens of proteins (Paz et al., 2011).
