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During the entire follow-up period, a passive case detection system was maintained at the Ilaita health sub-centre and Sikamo aid post.
While a consistent association between higher (vs. lower) anti-CS response and protection against P. falciparum infection was seen in challenge studies [18], [24], [25] and in field trials with active detection of infection [6], such an association was not found with malaria disease, as captured in a passive case detection system [8].
The MRL uses a passive case detection system, which relies on the clinician or laboratory to report malaria cases.
The MRL operates a passive case detection system, so under-reporting is inevitable, though the capture rate is estimated to be at least 66%.
In India, a passive case detection method is followed under the Revised National Tuberculosis Control Program RNTCPP) for TB case-finding.
Under-reporting is inevitable in a passive case detection system, although capture-recapture data suggest that levels of reporting are high.
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The RNTCP, based on a "passive" case-finding strategy appears to have had an impact in relation to the availability and accessibility of quality TB services provided through government health facilities.
Another limitation of our study is the use of a passive case-finding approach, possibly leading to an overestimation of the time to IRIS and to under-recognition of certain self-limited IRIS presentations.
In this period in Bahia, 12,413 cases of VL were reported by using a passive case-detection procedure.
In Mayotte, concurrent with an enhanced passive case notification system, we carried out two surveys.
Cases of clinical malaria and malaria infection by P. falciparum were ascertained by a combination of passive case detection (PCD) and active detection of infection (ADI) as described elsewhere [10].
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