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The phrase "a particularly major issue" is correct and usable in written English.
It can be used to emphasize the significance of a specific problem or concern in a discussion or analysis.
Example: "The report highlighted a particularly major issue regarding the environmental impact of the proposed project."
Alternatives: "a notably significant issue" or "an especially important issue".
Exact(1)
This could be a particularly major issue with New Zealand data, because the field plots are small (0.04 hectares) and geopositioning was not conducted with a survey-grade (i.e. differential) GPS.
Similar(59)
This is a particularly major advance.
The issue of single sex wards is a still a major issue, particularly when considering the increase in black women receiving inpatient care.
Hannah Davenly, a student at SOAS in London, also highlights housing as a major issue, particularly for students in London.
Most participants mentioned health workforce as crucial to HSS with health worker capacity a major issue "particularly in areas that have been subjected to a prolonged conflict" (P8).
The issue of maintenance and repair/upgrading of existing structures has become a major issue, particularly extending the service lifespan of bridges.
The economic and time constraints in the repair or upgrading of existing infrastructure have become a major issue, particularly extending the service lifespan of bridges.
The speech will also reference hot-button issues in the community related to law enforcement – domestic violence, the cyberbulling and grooming of children online, and the ice epidemic, which is a major issue, particularly in regional Australia.
Underreporting and under diagnosis is considered to be a major issue, particularly among adults.
Access to safe water and sanitation remains a major issue, particularly in rural areas.
2 4 MRPs represent a major issue, particularly in chronic conditions such as cardiovascular diseases (CVDs) and diabetes mellitus (DM).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com