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The phrase "a particularly fundamental problem" is correct and usable in written English.
You can use it when discussing an issue that is essential or core to a larger topic or situation, emphasizing its significance.
Example: "In our research, we identified a particularly fundamental problem that affects the overall outcome of the project."
Alternatives: "a notably essential issue" or "a distinctly core challenge".
Exact(1)
The subjective judgment generally inherent in quality assessment is a particularly fundamental problem for the Philips guidelines [ 24].
Similar(59)
Their view is that acquaintance is a particularly fundamental sort of psychological, hence natural, relation.
That's a problem, a fundamental problem, in human society.
This is more a nuisance than a fundamental problem.
The way people get around, particularly in big cities like New York, is changing rapidly, but a fundamental problem remains unsolved: how to best size and operate a fleet of vehicles, especially traditional taxis and particularly given taxi riders' attitudes toward sharing.
But there is a more fundamental problem.
"There's a more fundamental problem here.
There is also a quite fundamental problem.
Yet, the exposé cloaks a more fundamental problem.
But there is a more fundamental problem between Western Europe and America.
Georg: We believe that there is a more fundamental problem.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com