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The phrase "a particularly difficult subject" is correct and usable in written English.
You can use it when discussing a topic that is notably challenging or complex, often in an academic or educational context.
Example: "Mathematics is often considered a particularly difficult subject for many students."
Alternatives: "an especially challenging topic" or "a notably tough subject".
Exact(3)
Ms Stacey also told the cross-party group of MPs that English was a particularly difficult subject to set standards for and there was a "large element of judgment" involved in marking the exams.
Yet, especially today, it seems that is a particularly difficult subject, perhaps most so for western leaders who up until very recently have prided themselves on representing Democracy.
Moreover, bioenergetics was not a particularly difficult subject for the students.
Similar(57)
Getting a parent or grandparent set up with True Link does, of course, mean introducing the particularly difficult subject of restricting their financial independence.
For any photographer, birds are particularly difficult subjects to capture, and for Yola the question of how to control them was both a practical problem and a creative challenge.
ImClone reports that in a study of 40 patients with pancreatic cancer, a particularly difficult cancer to treat, the test subjects had a 33% one-year survival rate when given IMC-C225 in combination with conventional chemotherapy.
Against this background of a perceived reluctance on the part of doctors to give out additional information willingly, patients are likely to have a particularly difficult time finding out about CAM, a subject about which doctors themselves may have limited knowledge or interest or about which they may hold views which are at variance with those of their patients.
We have come together to address a subject that many Americans seem to have a particularly difficult time talking openly and reasonably about -- racism.
For example, rather than praising every good grade on a test in a subject that's easy for your child, praise the effort it took to finish a particularly difficult math worksheet.
Mr. Huntsman has a particularly difficult challenge.
Pakistan poses a particularly difficult problem.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com