The phrase "a particularly challenging problem" is correct and usable in written English.
You can use it when describing a problem that is notably difficult or complex, often in academic, professional, or analytical contexts.
Example: "The researchers faced a particularly challenging problem when trying to find a solution to the environmental crisis."
Alternatives: "an especially difficult issue" or "a notably tough challenge."
Among these issues, traffic accidents present a particularly challenging problem.
A particularly challenging problem arises when the contaminants (or solutes) are comprised of a mixture of volatile and nonvolatile compounds.
This approach has been also applied to the solution of a particularly challenging problem that remained unresolved for over a decade [44].
This is a particularly challenging problem because efficient communication requires tight coevolution between the signal emitted and the response elicited [3].
Determination of a speaker's emotion or mental state is a particularly challenging problem, in view of the significant variability in its expression posed by linguistic, contextual, and speaker-specific characteristics within speech.
In the PDT field, the measurement of oxygen concentration during PDT is a particularly challenging problem due to real-time changes in oxygen demand and supply during the treatment.
A novel and comprehensive computational method, referred to as the eXtended Algebraic Variational Multiscale-Multigrid-Multifractal Method (XAVM4), is proposed for large-eddy simulation of the particularly challenging problem of turbulent two-phase flow.
One particularly challenging problem is to predict prognostic outcome of the disease for different patients.
According to The New Yorker, the chef reacted as if he'd just been handed a particularly challenging logic problem.
Wound healing impairment represents a particularly challenging clinical problem to which no efficacious treatment regimens currently exist.
Malignant glioblastoma represents a particularly challenging clinical problem because these cells migrate avidly along many routes beyond the boundaries of the main tumor mass.
