Repositories of possible zinc fingers recognizing particular trinucleotide sequences are readily available [ 63, 64].
XX refers to a particular dinucleotide and XXX for a particular trinucleotide.
The mutation frequency for a given trinucleotide sequence is therefore proportional to e(−VSSE/ kT ).
The disorder is caused by dynamic mutation of a single trinucleotide sequence, CGG, on the X chromosome.
One example is Huntington's disease (HD), which is caused by a genetic mutation where a specific trinucleotide sequence is repeated a variable number of times, and persons with a number of these repeated trinucleotides over a certain threshold will develop HD.
The origin of DM is an expansion of the trinucleotide sequence CTG in the 3'-untranslated region (UTR) of the DMPK gene.
A3G preferentially edits the third cytidine in a 5'-CCC-3' trinucleotide sequence context on single stranded DNA, whereas it is unable to edit double stranded DNA or DNA/RNA hybrids [6], [23], [24].
A number of trinucleotide sequences in DNA can form compact and stable hairpin loops that may have significance for DNA replication and transcription.
To test whether SSRs were more likely to involve a particular sequence motif, we developed a posterior probability distribution of each di- and trinucleotide repeat type (e.g. AG, ACT, etc).
It consists of a particular sequence of decision opportunities.
It then finds a particular sequence called a start codon.
